## Table 3 |
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Results of PAML analyses for the primate dataset |
|||||

Data set |
2ΔlnL |
df |
P-value |
Proportion of sites with ω > 1 (average ω for these sites) |
Positively selected codons^{a} |

All NAT coding sequences (n= 43) |
|||||

M1a vs. M2a | 0 | 2 | P = 1.0 |
none | |

M7 vs. M8 | 3.49 | 2 | P = 0.17 |
none | |

M0 vs. free ratios | 114.89 | 80 | P= 0.006 |
||

Orthologous sequences to human NAT1 (n= 19) |
|||||

M1a vs. M2a | 0 | 2 | P = 1.0 |
none | |

M7 vs. M8 | 0 | 2 | P = 1.0 |
none | |

M0 vs. free ratios | 49.09 | 34 | P= 0.04 |
||

Orthologous sequences to human NAT2 (n= 19) |
|||||

M1a vs. M2a | 8.48 | 2 | P= 0.01 |
0.038 (ω = 4.8) | |

M7 vs. M8 | 11.24 | 2 | P= 0.004 |
0.041 (ω = 4.6) | 191*, 173* |

M0 vs. free ratios | 27.52 | 34 | P = 0.77 |

*n*, number of sequences; 2Δln*L*, twice the log-likelihood difference of the models compared; df, degrees of freedom;
*P*-value, level of significance (*P*-values < 0.05 are shown in bold).

^{a} Sites pinpointed to be under positive selection under the selection model with the
highest likelihood (M8 for the set of *NAT2* orthologous sequences) by Bayes Empirical Bayes (BEB) analysis. Only sites with posterior
probability greater than 0.95 (*) or 0.99 (**) are shown. Sites are numbered according
to the full human coding sequence.

Sabbagh * et al.*

Sabbagh * et al.* *BMC Evolutionary Biology* 2013 **13**:62 doi:10.1186/1471-2148-13-62