Additional file 3: Figure S2.

Gene order and orientation in regions surrounding the NAT genes on human (Homo sapiens) and mouse (Mus musculus) chromosome 8. Gene lengths and intergenic distances are not drawn to scale. Double slashes (//) indicate continuing sequence data extending toward the centromeric (cen) and telomeric (tel) parts of the chromosome. Grey boxes indicate NAT-like sequences. The region encompassing the three NAT loci spans approximately 190 kb in human, but less than 60 kb in mouse. In humans, two of the loci are functional (NAT1 and NAT2) and one is a pseudogene (NATP). In mice, all three appear to generate functional transcripts, although no apparent specific substrate for the product of the third locus (Nat3) has been identified. Interestingly, Mouse Nat2 is considered as the functional equivalent of human NAT1, based on substrate profile, tissue distribution and expression during development (see [10] for review).

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Sabbagh et al. BMC Evolutionary Biology 2013 13:62   doi:10.1186/1471-2148-13-62