Table 5

Phosphorylation sites predictions for human sirtuins
NetPhos Group based prediction system (GPS) Phosphosite
N-term Core C-term N-term Core C-term N-term Core C-term
SIRT1 13(27%) 5(10%) 30(63%) 20(25%) 10(13%) 50(62%) 8(38%) 1(5%) 12(57%)
SIRT2 5(22%) 11(48%) 7(30%) 8(18%) 28(62%) 9(20%) 3(33%) 2(22%) 4(45%)
SIRT3 8(50%) 7(44%) 1(6%) 11(35%) 17(55%) 3(10%) 0(0%) 2(100%) 0(0%)
SIRT4 1(11%) 8(89%) 0(0%) 5(18%) 23(82%) 0(0%) 0(0%) 2(100%) 0(0%)
SIRT5 4(29%) 10(71%) 0(0%) 5(19%) 21(78%) 1(03%) 0(0%) 4(100%) 0(0%)
SIRT6 2(11%) 11(58%) 6(31%) 4(11%) 25(66%) 9(23%) 1(13%) 1(13%) 6(74%)
SIRT7 5(19%) 16(62%) 5(19%) 6(13%) 31(65%) 11(22%) 0(0%) 0(0%) 0(0%)

We report the prediction obtained by Netphos and GPS. Phosphosite was used as additional reference, though it contains few data about sirtuins. GPS is specific for human sirtuins. In the rows are indicated the total number of phosphosites for segment and in parenthesis the percentage on the total number of phosphosites in the given protein.

Costantini et al.

Costantini et al. BMC Evolutionary Biology 2013 13:60   doi:10.1186/1471-2148-13-60

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