Additional file 3.
Methionine salvage pathway. Enzymes surrounded by a thick gray box were shown to be horizontally transferred from Bacteria (see main text). Metabolites – I: methionine; II: S-adenosylmethionine; III: S-adenosylmethioninamine; IV: S-methyl-5-thioadenosine; V: S-methyl-5-thioribose; VI: S-methyl-5-thioribose 1-phosphate; VII: S-methyl-5-thioribulose 1-phosphate; VIII: 2,3-diketomethylthiopentyl-1-phosphate; IX: 2-hydroxy-3-keto-5-methylthiopenctenyl-1-phosphate; X: 1,2-dihydroxy3-keto-5-methylthiopentene; XI: 4-methylthio-2-oxobutanoate. Enzymes – 220.127.116.11: methionine adenosyltransferase; 18.104.22.168: adenosylmethionine decarboxylase; 22.214.171.124: spermidine synthase; 126.96.36.199: adenosylhomocysteine nucleosidase; 188.8.131.52: methylthioadenosine nucleosidase; 184.108.40.206: S-methyl-5-thioribose kinase; 220.127.116.11: S-methyl-5’-thioadenosine phosphorylase; 18.104.22.168: S-methyl-5-thioribose-1-phosphate isomerase; 22.214.171.124: methylthioribulose 1-phosphate dehydratase; 126.96.36.199: acireductone synthase; 188.8.131.52: acireductone dioxygenase; 184.108.40.206: tyrosine transaminase; 220.127.116.11: aromatic-amino-acid transaminase. SHT: symbiont-harboring trypanosomatid; RT: regular trypanosomatid; TPE: trypanosomatid proteobacterial endosymbiont.
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Alves et al. BMC Evolutionary Biology 2013 13:190 doi:10.1186/1471-2148-13-190