Additional file 3.

Methionine salvage pathway. Enzymes surrounded by a thick gray box were shown to be horizontally transferred from Bacteria (see main text). Metabolites – I: methionine; II: S-adenosylmethionine; III: S-adenosylmethioninamine; IV: S-methyl-5-thioadenosine; V: S-methyl-5-thioribose; VI: S-methyl-5-thioribose 1-phosphate; VII: S-methyl-5-thioribulose 1-phosphate; VIII: 2,3-diketomethylthiopentyl-1-phosphate; IX: 2-hydroxy-3-keto-5-methylthiopenctenyl-1-phosphate; X: 1,2-dihydroxy3-keto-5-methylthiopentene; XI: 4-methylthio-2-oxobutanoate. Enzymes – 2.5.1.6: methionine adenosyltransferase; 4.1.1.50: adenosylmethionine decarboxylase; 2.5.1.16: spermidine synthase; 3.2.2.9: adenosylhomocysteine nucleosidase; 3.2.2.16: methylthioadenosine nucleosidase; 2.7.1.100: S-methyl-5-thioribose kinase; 2.4.2.28: S-methyl-5’-thioadenosine phosphorylase; 5.3.1.23: S-methyl-5-thioribose-1-phosphate isomerase; 4.2.1.109: methylthioribulose 1-phosphate dehydratase; 3.1.3.77: acireductone synthase; 1.13.11.54: acireductone dioxygenase; 2.6.1.5: tyrosine transaminase; 2.6.1.57: aromatic-amino-acid transaminase. SHT: symbiont-harboring trypanosomatid; RT: regular trypanosomatid; TPE: trypanosomatid proteobacterial endosymbiont.

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Alves et al. BMC Evolutionary Biology 2013 13:190   doi:10.1186/1471-2148-13-190