Overview of the biosynthetic pathways of essential amino acids in trypanosomatids. Dashed arrows: metabolite import; dotted arrows: reaction present in only some of the organisms analyzed; solid arrows: other reactions (a single arrow can summarize multiple steps); arrows surrounded by a gray box: enzymes possibly acquired through horizontal transfer from Bacteria to trypanosomatids (see main text). A. Contribution of symbiont-harboring trypanosomatids (SHT) and endosymbionts (TPE) based on the analysis of gene content in the genomes of A. deanei, A. desouzai, S. culicis, S. oncopelti, S. galati, and respective endosymbionts. B. Biochemical capability of trypanosomatids without symbionts (RT), based on the analysis of genomic data from H. muscarum, C. acanthocephali, and L. major.
Alves et al. BMC Evolutionary Biology 2013 13:190 doi:10.1186/1471-2148-13-190