Figure 6.

Histidine synthesis pathway. Enzymes surrounded by a thick gray box were shown to be horizontally transferred from Bacteria (see main text). Metabolites – I: 5-phosphoribosyl diphosphate (PRPP); II: phosphoribosyl-ATP; III: phosphoribosyl-AMP; IV: phosphoribosyl-formimino-AICAR phosphate; V: phosphoribulosyl-formimino-AICAR phosphate; VI: imidazole-glycerol 3-phosphate; VII: imidazole-acetol phosphate; VIII: histidinol phosphate; IX: histidinol; X: histidinal; XI: histidine. Enzymes – ATP phosphoribosyltransferase; phosphoribosyl-ATP pyrophosphohydrolase; phosphoribosyl-AMP cyclohydrolase; phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; 4.1.3.-: cyclase HisF; 2.4.2.-: glutamine amidotransferase; imidazole-glycerol phosphate dehydratase; histidinol phosphate aminotransferase; histidinol phosphatase; histidinol dehydrogenase. Abbreviations as for Figure 1.

Alves et al. BMC Evolutionary Biology 2013 13:190   doi:10.1186/1471-2148-13-190
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