Figure 6.

Histidine synthesis pathway. Enzymes surrounded by a thick gray box were shown to be horizontally transferred from Bacteria (see main text). Metabolites – I: 5-phosphoribosyl diphosphate (PRPP); II: phosphoribosyl-ATP; III: phosphoribosyl-AMP; IV: phosphoribosyl-formimino-AICAR phosphate; V: phosphoribulosyl-formimino-AICAR phosphate; VI: imidazole-glycerol 3-phosphate; VII: imidazole-acetol phosphate; VIII: histidinol phosphate; IX: histidinol; X: histidinal; XI: histidine. Enzymes – 2.4.2.17: ATP phosphoribosyltransferase; 3.6.1.31: phosphoribosyl-ATP pyrophosphohydrolase; 3.5.4.19: phosphoribosyl-AMP cyclohydrolase; 5.3.1.16: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; 4.1.3.-: cyclase HisF; 2.4.2.-: glutamine amidotransferase; 4.2.1.19: imidazole-glycerol phosphate dehydratase; 2.6.1.9: histidinol phosphate aminotransferase; 3.1.3.15: histidinol phosphatase; 1.1.1.23: histidinol dehydrogenase. Abbreviations as for Figure 1.

Alves et al. BMC Evolutionary Biology 2013 13:190   doi:10.1186/1471-2148-13-190
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