Threonine synthesis pathway. Enzymes surrounded by a thick gray box were shown to be horizontally transferred from Bacteria (see main text). Metabolites – I: glycine; II: threonine; III: phosphohomoserine; IV: homoserine; V: aspartate 4-semialdehyde; VI: 4-aspartyl-phosphate; VII: L-aspartate. Enzymes – 188.8.131.52: threonine aldolase; 184.108.40.206: aspartate kinase; 220.127.116.11: aspartate-semialdehyde dehydrogenase; 18.104.22.168: homoserine dehydrogenase; 22.214.171.124: homoserine kinase; 126.96.36.199: threonine synthase. Abbreviations as for Figure 1.
Alves et al. BMC Evolutionary Biology 2013 13:190 doi:10.1186/1471-2148-13-190