Figure 1.

DAP pathway for lysine biosynthesis. Enzymes surrounded by a thick gray box were shown to be horizontally transferred from Bacteria (see main text). Metabolites – I: L-aspartate; II: 4-aspartyl-phosphate; III: aspartate 4-semialdehyde; IV: 2,3-dihydrodipicolinate; V: 2,3,4,5-tetrahydrodipicolinate; VI: N-succinyl-L-2-amino-6-oxopimelate; VII: N-succinyl-LL-2,6-diaminopimelate; VIII: LL-2,6-diaminopimelate; IX: meso-2,6-diaminopimelate; X: lysine. Enzymes – 2.7.2.4: aspartate kinase; 1.2.1.11: aspartate-semialdehyde dehydrogenase; 4.2.1.52: dihydrodipicolinate synthase; 1.3.1.26: dihydrodipicolinate reductase; 2.3.1.117: tetrahydrodipicolinate succinyltransferase; 2.6.1.17: succinyldiaminopimelate transaminase; 3.5.1.18: succinyldiaminopimelate desuccinylase; 5.1.1.7: diaminopimelate epimerase; 4.1.1.20: diaminopimelate decarboxylase. SHT: symbiont-harboring trypanosomatid; RT: regular trypanosomatid; TPE: trypanosomatid proteobacterial endosymbiont.

Alves et al. BMC Evolutionary Biology 2013 13:190   doi:10.1186/1471-2148-13-190
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