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Open Access Research article

Adaptive evolution of the osmoregulation-related genes in cetaceans during secondary aquatic adaptation

Shixia Xu, Yunxia Yang, Xuming Zhou, Junxiao Xu, Kaiya Zhou and Guang Yang*

Author Affiliations

Jiangsu Key Laboratory for Biodiversity and Biotechnology, College of Life Sciences, Nanjing Normal University, 1 Wenyuan Road, Nanjing 210023, China

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BMC Evolutionary Biology 2013, 13:189  doi:10.1186/1471-2148-13-189

Published: 9 September 2013

Additional files

Additional file 1: Figure S1:

A well supported phylogeny of mammals used for selective pressure analysis in PAML. Tree topologies of Laurasiatheria and primates were from Zhou et al. [56] and Perelman et al. [57], respectively. Different orders of mammals were marked with different colors. Branches a–u in the tree included in cetaceans are used in the branch-site models tests, and results listed in Table 1 and Figure 1.

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Additional file 2: Table S1:

Radical or conservative changes occurred at positively selected sites detected in cetaceans using the site models and branch-site models.

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Additional file 3: Figure S2:

Spatial distribution of positively selected sites in the three-dimensional (3D) structure of cetacean ACE (A), AGT (B), AQP2 (C), SLC14A2 (D) genes. The 3D structure of ACE and UTA contains two (a1-ACE and a2-ACE) and three domains (d1- SLC14A2, d2- SLC14A2, d3- SLC14A2), respectively. All the positively selected sites were mapped onto 3D structure of each gene.

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Additional file 4: Table S2:

Sequence data used in this study, including taxonomy and accession numbers or Ensembl ID.

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