Additional file 4: Figure S4.
Network of coevolution among amino acid sites in GroEL in different bacterial groups. We identified coevolution between GroEL residues in six bacterial groups, including Actinobacteria (a), Bacteroidetes (b), Cyanobacteria (c), Spirochaetes (d), Firmicutes (e) and Proteobacteria (f). We used amino acid numberings according to the position of the site in the crystal structure of GroEL from Escherichia coli (PDB ID: 1AON, MMDB ID: 47936). The position of the sites in the three domains of GroEL, equatorial, apical and intermediate, is color-coded.
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Ruiz-González and Fares BMC Evolutionary Biology 2013 13:156 doi:10.1186/1471-2148-13-156