Additional file 3: Figure S3.

Network of coevolution among amino acid sites in GroES in different bacterial groups. To identify shifts in the coevolution networks, we analyzed coevolution in GroES in the different bacterial groups and identified amino acid sites with evolutionary dependencies in three groups: coevolution network in Actinobacteria (a); Firmicutes (b) and Proteobacteria (c). We used the numbering of sites according to the structure of GroEL from Escherichia coli (PDB ID: 1AON, MMDB ID: 47936).

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Ruiz-Gonz├ílez and Fares BMC Evolutionary Biology 2013 13:156   doi:10.1186/1471-2148-13-156