Figure 2.

Coevolution between GroES and GroEL. The network of residues involved in the evolutionary dependency between GroES and GroEL identifies 7 residues from GroES and 8 from GroEL (a) Structural mapping of coevolving residues reveals the functional importance of coevolving residues (b) residues coevolving between both proteins belong to substrate binding regions, inter-subunit and inter-ring contacts.

Ruiz-Gonz├ílez and Fares BMC Evolutionary Biology 2013 13:156   doi:10.1186/1471-2148-13-156
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