Table 2

Summary of relevant results: Genes putatively affected by positive selection. Loci showing gene-level iHS extreme empirical p-value after Bonferroni multiple comparison correction is considered taking into account the number of continental groups and the two methods applied
Sub-pathway Gene Continental Group p-value Corrected p-values
Precursor Biosynthesis ALG12 MENA 3 × 10-10 4.2 × 10-9
EUR 1 × 10-10 1.4 × 10-9
EASIA 5 × 10-11 7.0 × 10-10
GANAB SSAFR 4 × 10-7 5.6 × 10-6
CNX_CRT EDEM3 OCE 1 × 10-10 1.4 × 10-9
GCS1 MENA 2 × 10-14 2.8 × 10-13
EUR 2 × 10-16 2.8 × 10-15
CSASIA 2 × 10-6 2.8 × 10-5
UGCGL2 SSAFR 4 × 10-5 5.6 × 10-4
Branching 1 FUT8 SSAFR 1 × 10-4 1.4 × 10-3
MAN1A1 AME 5 × 10-13 7.0 × 10-12
MAN1A2 SSAFR 8 × 10-4 1.12 × 10-2
MAN2A1 SSAFR 4 × 10-23 5.6 × 10-22
EASIA 3 × 10-10 4.2 × 10-9
MGAT2 EASIA 4 × 10-7 5.6 × 10-6
MGAT3 EASIA 1 × 10-14 1.4 × 10-13
Branching 2 MGAT5B MENA 1 × 10-7 1.4 × 10-6
EUR 7 × 10-8 9.8 × 10-7
ST8SIA3 MENA 5 × 10-10 7.0 × 10-9
EUR 2 × 10-8 2.8 × 10-7
Substrates DPM1 MENA 5 × 10-12 7.0 × 10-11
EUR 1 × 10-8 1.4 × 10-7
CSASIA 2 × 10-16 2.8 × 10-15
DOLPP1 CSASIA 2 × 10-5 2.8 × 10-4
DPM2 EUR 5 × 10-7 7.0 × 10-6
DPM3 EASIA 6 × 10-30 8.4 × 10-29

Populations were grouped as following: SSAFR, MENA, EUR, CSASIA, EASIA, OCE and AME standing respectively for Sub-Saharan Africa, Middle East-North Africa, Europe, Central South Asia, East Asia, Oceania and America.

Dall’Olio et al.

Dall’Olio et al. BMC Evolutionary Biology 2012 12:98   doi:10.1186/1471-2148-12-98

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