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Open Access Highly Accessed Research article

Evolution of the eukaryotic dynactin complex, the activator of cytoplasmic dynein

Björn Hammesfahr and Martin Kollmar*

Author Affiliations

Abteilung NMR basierte Strukturbiologie, Max-Planck-Institut für Biophysikalische Chemie, Am Fassberg 11, Göttingen D-37077, Germany

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BMC Evolutionary Biology 2012, 12:95  doi:10.1186/1471-2148-12-95

Published: 22 June 2012

Additional files

Additional file 1:

Zip archive of the Maximum Likelihood and Bayesian inference trees, and the sequence alignments of the dynactin subunits. The file includes all Maximum Likelihood and Bayesian trees of all dynactin proteins in the Newick format. The sequence alignments of the proteins are included in fasta format.

Format: PDF Size: 667KB Download file

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Open Data

Additional file 2:

Dynactin inventory of the analysed species. The file lists the presence and number of orthologs for each dynactin subunit for each analysed organism in taxonomic order.

Format: PDF Size: 511KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data

Additional file 3:

Phylogenetic tree of dynactin1. The file contains the phylogenetic tree of dynactin1 highlighting the species- and branch-specific gene duplication events.

Format: PDF Size: 553KB Download file

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Open Data

Additional file 4:

Detailed description of the pseudo-transcripts of dynactin4. The file contains details about the pseudo-transcripts of dynactin4

Format: PDF Size: 483KB Download file

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Open Data

Additional file 5:

Sequence alignment of fungal dynactin4 proteins. The file contains the sequence alignment of the N-termini of several fungal dynactin4 (p62) subunits showing that the upstream methionines in Neurospora and Sordaria are most likely not the translation start sites.

Format: PDF Size: 986KB Download file

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Open Data

Additional file 6:

Phylogenetic tree of Arp1. The file contains the phylogenetic tree of Arp1 focused on the vertebrate branch highlighting the Arp1 gene duplication event and subsequent branch-specific losses of Arp1 subtypes.

Format: PDF Size: 181KB Download file

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Open Data

Additional file 7:

Discussion of the evolution of the Cap proteins. The file contains a discussion of the gene duplications, which happened to the Capα (Cap1) subunit, and of alternative splice variants of the Capβ (Cap2) subunit [120,121].

Format: PDF Size: 219KB Download file

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Open Data

Additional file 8:

Species table. The file contains all species of the analysis, their scientific names, the abbreviation as used in the sequence alignments and trees, the species taxonomy, references to sequencing centers, and publications if genome analyses have already been published.

Format: PDF Size: 5.5MB Download file

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Open Data