Table 1

The phylogenetic distribution of CL biosynthesis and maturation enzymes of five eukaryotic supergroups

CL biosynthesis

CL maturation


Organism

CLD

Step one

Step two


CLS_cap

CLS_pld

iPLA2–γ

iPLA2–β

ALCAT

TAZ



Homo sapiens

+

-

+

+

+

+

+


Mus musculus

+

-

+

+

+

+

+


Animalia

Xenopus laevis

+

-

+

+

+

+

+


Gallus gallus

+

-

+

+

+

+

+


Danio rerio

+

-

+

+

+

+

+


Drosophila melanogaster

+

-

+

-

+

-

+


Opisthokonta

Caenorhabditis elegans

+

-

+

+

+

+

+


Hydra magnipapillata

+

-

+

+

+

+a


Strongylocentrotus purpuratus

+

-

+

+

+

+

+


Schistosoma mansoni

+

-

+

+

+

+


Ciona intestinalis

+

-

+

+

+

+

+


Choanoflagellete

Monosiga brevicollis

+

-

+

-

-

+

+


Fungi

Saccharomyces cerevisiae

+

-

+

-

-

+

+


Ascomycota

Schizosaccharomyces pombe

+

-

+

-

+

-


Aspergillus fumigatus

+

-

+

-

+

+

+


Basidiomycota

Ustilago maydis

+

-

+

-

-

+

+


Cryptococcus

neoformans

+

-

+

-

-

+

+


Antonospora locustae

-

-

-

-

-

-

-


Encephalitozoon cuniculi

-

-

-

-

-

-

-


Microsporidia

Enterocytozoon bieneusi

-

-

-

-

-

-

-


Encephalitozoon intestinalis

-

-

-

-

-

-

-


Amoebozoa

Mycetozoa

Dictyostelium discoideum

-

+

-

-

+

+

+


Dictyostelium purpureum

-

+

-

-

+

+

+


Entamoebida

Entamoeba histolytica

-

-

-

-

-

-

-


Entamoeba dispar

-

-

-

-

-

-

-


Entamoeba invadens

-

-

-

-

-

-


Archaeplastida

Planta

Arabidopsis thaliana

+

-

+

+

-

+

+


Oryza sativa

+

-

+

+

-

+

+


Chlorophyta

Chlamydomonas reinhardtii

+

-

+

+

-

-

+


Ostreococcus lucimarinus

+

-

+

-

-

+


Ostreococcus tauri

+

-

+

-

+


Micromonas sp.

+

-

+

+

-

+

+


Rhodophyta

Cyanidioschyzon merolae

+

-

+

+

-

-

+


Galdieria sulphuraria #

+a

-

-

-

-

-

+a


Chromalveolata

Alveolata

Ciliata

Tetrahymena thermophila

-

+

+

-

-

-

-


Paramecium tetraurelia

-

+

+

-

-

-

-


Perkinsida

Perkinsus marinus

-

+

-

+

-

-

-


Plasmodium knowlesi

-

+

-

+

-

-

-


Plasmodium vivax

-

+

-

+

-

-

-


Plasmodium faciparum

-

+

-

+

-

-

-


Apicomplexa

Plasmodium chabaudi

-

+

-

+

-

-

-


Plasmodium yoelli yoelii

-

+

-

+

-

-

-


Cryptosporidium parvum

-

+

-

-

-

-

-


Cryptosporidium hominis

-

+

-

-

-

-

-


Cryptosporidium muris

-

+

-

-

-

-

-


Toxoplasma gondii

-

+

-

+

-

-

-


Babesia bovis T2Bo

-

+

-

+

-

-

-


Theileria parva

-

+

-

+

-

-

-


Theileria annulata

-

+

-

+

-

-

-


Pythium ultimum

+

-

+

-

-

+

+


Phytophthora sojae

+

-

+

-

-

+


Oomycetes

Phytophthora ramorum

+

-

+

-

-

+

+


Phytophthora infestans

+

-

+

-

-

+

+


Stramenopiles

Saprolegnia parasitica

+

-

+

-

-

+

+


Blastocystis hominis *

-

-

-

-

-

+

+


Bacillariophyta

Thalassiosira

pseudonana

+

-

+

+

-

-

+


Phaeodactylum tricornutum

+a

-

+

+

-

+

-


Phaeophyceae

Ectocarpus siliculosus

+

-

+

+

-

+

+


Excavata

Kinetoplastids

Leishmania braziliensis

-

+

+

-

-

+

-


Leishmania infantum

-

+

+

-

-

+

-


Leishmania major

-

+

+

-

-

+

-


Trypanosoma brucei

-

+

+

-

-

+

-


Trypanosoma cruzi

-

+

-

-

-

+

-


Heterolobosea

Naegleria gruberi

+

-

+

-

+


Parabasalia

Trichomonas vaginalis

-

-

-

-

-

-

-


Diplomonadida

Giardia lamblia

-

-

-

-

-

-

-


+ = presence; - = absence; a, homologs obtained by tblastn search rather than by blastp search as others; *, nr database rather than genome database was searched against for homologs; #, EST database rather than genome database was searched against for homologs

Tian et al. BMC Evolutionary Biology 2012 12:32   doi:10.1186/1471-2148-12-32

Open Data