Synteny of Mel1c/GPR50 genes and neighbours in vertebrate genomes. Note that genes are found on chromosome 5 in zebra fish and on chromosome 4 in chicken while they are found on chromosome X in other depicted species. Please note that synteny is mostly conserved for bHLHPAS, 2610030H06 RIK, Mel1c, HMG2A, CD99, and myotubularin related protein in opossum and mammalian species despite the integration of new genes coding for hypothetical proteins (opossum, chimpanzee, cow), ribosomal proteins (dog, chimpanzee, man), NGFI-A binding protein (chimpanzee, man), Utbf (mouse) and MAGE (cattle) proteins. It is also of note that several genes surrounding Mel1c in zebra fish (pdcd8, nono, and the two hypothetical proteins) present high identities with genes found on chromosome X in mouse but not in the GPR50 locus (unpublished data). p.d.: predicted gene. Chrm: chromosome.
Dufourny et al. BMC Evolutionary Biology 2012 12:28 doi:10.1186/1471-2148-12-28