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Open Access Correction

Correction: Proportionality between variances in gene expression induced by noise and mutation: consequence of evolutionary robustness

Kunihiko Kaneko

Author affiliations

Department of Basic Science, Univ. of Tokyo 3-8-1 Komaba, Meguro-ku, Tokyo 153-8902, Japan

Citation and License

BMC Evolutionary Biology 2012, 12:240  doi:10.1186/1471-2148-12-240

Published: 9 December 2012

First paragraph (this article has no abstract)

Although the simulation data as well as the conclusion on the proportionality between Vip(i) and Vg(i) in the work [1] is correct, interpretation of some data therein should be corrected. As the sampling number (L = 200) to measure the average gene expression level is not large enough, there is a bias in the estimate in Vg(i). Finiteness in the number of sampling L will generally cause a bias of the order of Vip(i)/L, in the estimate of the variance Vg(i). The too good proportionality between Vip(i) and Vg(i) for large σ, shown in Figure two (a)(b) of [1] (especially for small Vg(i)), is due to this artifact. Accordingly, the sharp peak at ∼1/L = 1/200 in Figure three of [1] is due to this insufficiency by the sample number.