Open Access Research article

Evolution of major histocompatibility complex class I and class II genes in the brown bear

Katarzyna Kuduk1, Wiesław Babik2, Katarzyna Bojarska1, Ewa B Śliwińska3, Jonas Kindberg4, Pierre Taberlet5, Jon E Swenson67 and Jacek Radwan1*

Author Affiliations

1 Institute of Environmental Sciences, Jagiellonian University, Gronostajowa 7, Kraków, 30-387, Poland

2 Institute of Systematics and Evolution of Animals, Polish Academy of Sciences, Sławkowska 17, Kraków, 31-016, Poland

3 Institute of Nature Conservation, Polish Academy of Sciences, Mickiewicza 33, Kraków, 31-120, Poland

4 Department of Wildlife, Fish, and Environmental Studies, Swedish University of Agricultural Sciences, Umeå, SE, 901 83, Sweden

5 Laboratoire d’Ecologie Alpine (LECA), Génomique des Populations et Biodiversité, CNRS UMR 5553, Université Joseph Fourier, BP 53, Grenoble Cedex 9, F-38041, France

6 Department of Ecology and Natural Resources Management, Norwegian University of Life Sciences, Ãs, NO-1432, Norway

7 Norwegian Institute for Nature Research, Trondheim, NO-7485, Norway

For all author emails, please log on.

BMC Evolutionary Biology 2012, 12:197  doi:10.1186/1471-2148-12-197

Published: 2 October 2012

Additional files

Additional file 1:

Table S1. Primer sequences for MHC class I and MHC class II in the brown.

Format: DOCX Size: 25KB Download file

Open Data

Additional file 2:

Supplementary information. Mammalian MHC sequences used to obtain the brown bear sequences used to design primers.

Format: DOCX Size: 33KB Download file

Open Data

Additional file 3:

Table S2. The number of MHC class I alleles detected in genomic DNA (gDNA) and transcribed alleles (cDNA).

Format: DOCX Size: 18KB Download file

Open Data

Additional file 4:

Table S3. The average pairwise nucleotide and amino-acid distances (A), dN and dS for brown bear MHC class I sequences (B).

Format: DOCX Size: 22KB Download file

Open Data

Additional file 5:

Nucleotide sequences of MHC class II DRB genes in the Scandinavian brown bear.

Format: DOCX Size: 31KB Download file

Open Data