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Open Access Highly Accessed Research article

The relationship between the hierarchical position of proteins in the human signal transduction network and their rate of evolution

David Alvarez-Ponce

Author Affiliations

Department of Biology, National University of Ireland Maynooth, Maynooth, County Kildare, Ireland

Instituto de Biología Molecular y Celular de Plantas, Consejo Superior de Investigaciones Científicas (CSIC)-Universidad Politécnica de Valencia (UPV), Valencia, Spain

BMC Evolutionary Biology 2012, 12:192  doi:10.1186/1471-2148-12-192

Published: 28 September 2012

Additional files

Additional file 1:

A single PDF file containing supplementary Tables S1–S5. Table S1 lists the results of the paired tests comparing the evolutionary rates of each gene with those of its direct downstream targets while controlling for a number of correlates of rates of evolution. Table S2 lists the Mann–Whitney tests comparing the evolutionary rates of genes occupying extreme upstream and downstream positions while controlling for a number of correlates of rates of evolution. Table S3 lists the partial correlation analyses contrasting the association between upstream/downstream position of genes and their rates of evolution while controlling for a number of correlates of rates of evolution. Table S4 lists the partial correlation analyses contrasting the association between rates of evolution and measures of hierarchical position while controlling for a number of correlates of rates of evolution. Table S5 lists the ω values for genes involved in the mammalian Ras signaling pathway.

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