Number of shared targets. Fraction of targets that are shared between pairs transcription factors in S. cerevisiae[26-28]. (left) The fraction of targets that are shared among paris of transcription factors that lack cooperative binding and (right) the fraction of targets that are shared among transcription factors that bind cooperatively. The fraction of targets that are shared is larger among cooperative factors (p < 2×10−16, Wilcoxon test).
Stewart et al. BMC Evolutionary Biology 2012 12:173 doi:10.1186/1471-2148-12-173