Cooperative binding accelerates adaptation. Cooperative binding accelerates adaptation under positive selection. The ratio of waiting times before the arrival of novel adaptive binding sites for populations without ( ) and with (tr) cooperative binding. Provided Ns > 1, cooperative binding reduces the adaptation time up to 10-fold, compared to populations that lack cooperative binding. The line shows our analytic expression, and points show the result of 105replicate Monte-Carlo simulations. Parameter values ul=2×10−7, ug=10−7, K1 + K2=100, h=10−1, t=10−4, N=104, ur=10−7.
Stewart et al. BMC Evolutionary Biology 2012 12:173 doi:10.1186/1471-2148-12-173