Regulatory complexity correlates with amount of ncDNA. a. The histogram of number of transcription factor binding sites (#TFBS) per transcription unit (TU) is given for each organism. The number of TFs represented in the results are given underneath the picture of the organism. b. A density map between the amount of upstream ncDNA per TU and the number of TFBS harbored within that region as a fraction of total reporting TFs is plotted for each organism. The provided correlation (r equation on plot) is the Pearson correlation coefficient, all with high (p<.001) significance. c. The regulatory properties for five model organisms is calculated as a fraction of total TFs per species. In the first panel, the each scatter point is labeled for the number provided each organism in a; because the average ncDNA length does not change, organisms follow the same order in subsequent panels. Each regulatory property does not necessarily scale between 0 to 1, as only ‘Degree’ is normalized over total TFs per species. A log linear regression is calculated and displayed with the Pearson correlation coefficient and p-value in parentheses.
Ruths and Nakhleh BMC Evolutionary Biology 2012 12:159 doi:10.1186/1471-2148-12-159