Table 1

Structural attributes and significant sites of the bHLH domain
Site Structural CS-F CS-A CS-P DT pah pss ms cc ec all
1 DP
2 DP * S SC S S
3
4
5 DP SC S
6 P S C
7
8 DP *
9 DP * C
10 P * * C C
11 P *
12 DP * * SC C C
13 DP SC SC S C
14
15 P * C C
16 B
17 P * *
18
19 *
20 B * * * C C C
21
22
23 B C C C C
24 *
25
26 *
27 B C C
28 B
50 DPB SC C C SC
51 * C C
52
53 B * C C
54 B C C C
55 S
56 S S
57 * * C
58
59
60 * *
61 B C
62
63
64 B

NOTE.–The molecular architechure of bHLH positions is compiled from previous work on crystalline structures of animal proteins. Structural attributes noted are DNA contact of the E-box (D), phosphate backbone contact (P), or buried site within the hydrophobic core of the dimerized helicies (B). Highly (√) and moderately (*) conserved sites are denoted for plant (CS-P), animal (CS-A), and fungal (CS-F) sequences. Sites integral in the decision tree analysis (DT) are also reported. Last, SWDA (S) and CVA (C) significant sites are shown within each factor score dataset (pah, pss, ms, cc, ec and all).

Sailsbery and Dean

Sailsbery and Dean BMC Evolutionary Biology 2012 12:154   doi:10.1186/1471-2148-12-154

Open Data