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Open Access Highly Accessed Research article

Exploring metazoan evolution through dynamic and holistic changes in protein families and domains

Zhengyuan Wang1, Dante Zarlenga2, John Martin1, Sahar Abubucker1 and Makedonka Mitreva134*

Author Affiliations

1 The Genome Institute, Washington University School of Medicine, 4444 Forest Park Blvd, St. Louis, MO 63108, USA

2 U.S. Department of Agriculture, Agricultural Research Service/ANRI, Animal Parasitic Diseases Lab, Beltsville, MD, 20705, USA

3 Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, MO, 63108, USA

4 Department of Genetics, Washington University School of Medicine, St. Louis, MO 63108, USA

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BMC Evolutionary Biology 2012, 12:138  doi:10.1186/1471-2148-12-138

Published: 3 August 2012

Additional files

Additional file 1:

Data summary of the species included in the analysis. The data provided represent summary of the number of proteins and domains per species and proteins within protein families.

Format: XLS Size: 25KB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data

Additional file 2:

IDs of protein families and their members. The data provided represent the accession numbers of the proteins grouped in protein families.

Format: XLS Size: 3.3MB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data

Additional file 3:

Groups of protein families with different taxonomic compositions. The provided table summarizes the numbers of protein families and their taxonomic distribution.

Format: XLS Size: 64KB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data

Additional file 4:

Trichinella spiralisspecific domains, their putative origin and function. List of the identified domains in T. spiralis having highest sequence similarity with non-metazoan species, their putative function and species of origin. (XLS 25 kb)

Format: XLS Size: 25KB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data