Additional file 1.

Table S1. Number and percentage of paralogs deemed to be asymmetrically evolving (FDR = 5 %) based on the whole protein and using Fisher Exact test (FET). Table S2. Number and percentage of paralogs deemed to be asymmetrically evolving (FDR = 0.01 %) based on the whole protein and using Fisher Exact test (FET). Table S3. Fisher exact test based analysis of asymmetrically evolving duplicate gene pairs using sampled codons to create artificial domains. Table S4. Number and percentage of paralogs deemed to be asymmetrically evolving (FDR = 10 %) based on the non-domain linker regions using Fisher Exact test (FET). Table S5. Duplicate gene pairs that contained multiple asymmetrically evolving domains categorized based on whether all the faster domains were in the same copy (Category 1) or distributed between the two copies (Category 2). Table S6. Frequency of occurrence of each of the protein domains and the fraction of times they were detected to be evolving asymmetrically (FET P-value < = 0.05, FDR < = 20 %). Supplementary Results. Differing regions of the gene duplicates are targeted for non-synonymous substitutions.

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Khaladkar and Hannenhalli BMC Evolutionary Biology 2012 12:126   doi:10.1186/1471-2148-12-126