Localisation of TLR5 sites of positive selection.A) predicted tertiary protein structure of bovine TLR5 and sites of positive selection. B) predicted tertiary protein structure of ECD and sites of positive selection and conserved amino acids within putative flagellin binding region. Black backbone depicts putative flagellin binding region; Light blue amino acids = Positive selection acting on all mammals (G104, H592, A659); Purple amino acids = Positive selection acting on domestic ungulates (L34, S268, I295, I307, I393, Q495, I621, E630); Orange amino acid = positive selection in sheep lineage (K326), Green amino acids and black arrows = positive selection in cattle lineage (I393,Q495,H720 ); Dark blue amino acids = Conserved amino acids predicted to be involved in the detection of flagellin.
Smith et al. BMC Evolutionary Biology 2012 12:122 doi:10.1186/1471-2148-12-122