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Open Access Research article

Phylogenomics of phosphoinositide lipid kinases: perspectives on the evolution of second messenger signaling and drug discovery

James R Brown1* and Kurt R Auger2

Author Affiliations

1 Computational Biology, Quantitative Sciences, GlaxoSmithKline, 1250 South Collegeville Road, UP1345, P.O. Box 5089, Collegeville PA 19426-0989, USA

2 Cancer Epigenetics, Oncology R&D, GlaxoSmithKline, 1250 South Collegeville Road, UP1110, P.O. Box 5089, Collegeville PA 19426-0989, USA

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BMC Evolutionary Biology 2011, 11:4  doi:10.1186/1471-2148-11-4

Published: 5 January 2011

Additional files

Additional file 1:

Accession numbers of protein sequences used in phylogenetic reconstructions. NCBI or EMBL accession numbers associated with the operational taxonomic labels (OTUs) for multiple sequence alignments in Additional files 2-5 which were used in phylogenetic reconstructions for Figures 2, 3, 4 and 7.

Format: XLSX Size: 33KB Download file

Open Data

Additional file 2:

Edited multiple sequence alignment of PI34K kinases. Multiple sequence alignment of PI34K kinases and related sequences used for phylogenetic reconstruction shown in Figure 2. Species, protein names and GenBank accession numbers (as identified by OTU label) are given in Additional file 1. Sequences are in MSF format with first line commenting on file contents.

Format: MSF Size: 58KB Download file

Open Data

Additional file 3:

Edited multiple sequence alignment of PI4K Type II kinases. Multiple sequence alignment of PI4K Type II and related sequences used for Figure 3. Species, protein names and GenBank accession numbers (as identified by OTU label) are given in Additional file 1. Sequences are in MSF format with first line commenting on file contents.

Format: MSF Size: 22KB Download file

Open Data

Additional file 4:

Edited multiple sequence alignment of PIPK kinases. Multiple sequence alignment of PIPK and related sequences used for Figure 4. Species, protein names and GenBank accession numbers (as identified by OTU label) are given in Additional file 1. Sequences are in MSF format with first line commenting on file contents.

Format: MSF Size: 35KB Download file

Open Data

Additional file 5:

Edited multiple sequence alignment of human PI34K and related kinases. Multiple sequence alignment of PI34K and related sequences used for Figure 7. Species, protein names and GenBank accession numbers (as identified by OTU label) are given in Additional file 1. Sequences are in MSF format with first line commenting on file contents.

Format: MSF Size: 3KB Download file

Open Data