Table 3

Positively selected sites predicted to affect TLR function based on their location in the three-dimensional structures

Gene

Position

Functional Information

Reference


TLR1

318

Close to sites involved in heterodimerization TLR1-TLR2 (315 and 320)

[16]


TLR2

302

LRR10 - involved in ligand binding


TLR3

79

LRR2 - dsRNA-TLR3 interaction site (LRR-NT to LRR3)

[22]


285

Adjacent to site of SNP (N284I) that confers partial or total loss of function


295

Adjacent to sites (294 and 296) involved in ligand binding


300

In the region involved in ligand binding


TLR4

301

In the region involved in ligand binding

[23]


317

In the region involved in ligand binding


363

In the region involved in ligand binding


441


459

Irregular LRR insertion before LRR15

[18]


TLR8

472


481

Irregular LRR insertion before LRR15 - Alanine residue mutation could affect TLR8 activation.

[18] and [47]


498

LRR15 - involved in ligand binding

[18]


Areal et al. BMC Evolutionary Biology 2011 11:368   doi:10.1186/1471-2148-11-368

Open Data