Table 1

The protein-like properties of sequence evolution over simulation time is shown

Simulation time

Model

Core

Surface

Gamma Support

Shape Parameter

Hydrophobicity

Hydrophobicity

(%)

(%)


5000

Informational

39.7

11.2

0.35

0.02


25000

Informational

42.1

15.2

0.72

0.95


50000

Informational

42.9

18.5

0.72

1.46


70000

Informational

45.0

20.4

0.69

1.55


100000

Informational

47.4

23.0

0.73

2.07


150000

Informational

47.7

27.7

0.49

2.61


200000

Informational

49.6

30.5

0.12

2.73


5000

Physics-based

83.4

49.2

0.20

3.31


25000

Physics-based

82.8

49.5

0.37

2.58


50000

Physics-based

81.7

49.1

0.31

2.06


70000

Physics-based

81.7

48.4

0.61

1.86


100000

Physics-based

81.1

48.6

0.09

1.87


150000

Physics-based

81.6

48.2

0.25

1.76


200000

Physics-based

81.1

48.0

0.10

1.88


Simulation time is listed in generations. Core and surface hydrophobicities shown reflect the population average percentage of hydrophobic residues in buried and exposed positions. Gamma support indicates the fractional support for a model including a gamma distribution of rates, and the shape parameter shows the α value of such a distribution.

Grahnen et al. BMC Evolutionary Biology 2011 11:361   doi:10.1186/1471-2148-11-361

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