dN/dS vs dS (proportional to simulation time) for surface (black), core (red) and binding site (green) residues is shown. Values reflect the mean of the most common allele in each population, with standard error bars indicating inter-population variation. Simulations using the informational scoring function in A), simulations using the physics-based scoring function in B).
Grahnen et al. BMC Evolutionary Biology 2011 11:361 doi:10.1186/1471-2148-11-361