Amino acids in the same evolutionary positions showing strong signatures of selection at the amino acids and the nucleotide level. Sites under positive selection confirmed by the different models used in this study for the dataset of 20 species (excluding rodents). The sites were numbered according to the Homo sapiens position [EMBL:ENST00000361056]. The results for SLAC, FEL, PAML (Model 8), TreeSAAP (at least one property under selection) and SLR are marked with a black box in the sites showing positive selection. The sites with more than three properties under selection in TreeSAAP are marked with a white plus symbol. The background colors represent the amino acids properties: polar positive (blue), polar negative (red and green), non-polar aliphatic (yellow), and P and G (pink).
Machado et al. BMC Evolutionary Biology 2011 11:342 doi:10.1186/1471-2148-11-342