Phylogeny of KCNA sequences. Left panel: Xenopus, chicken (Gallus), zebrafish (Danio), elephant shark (Callorhinchus) and human (Homo) KCNA sequences. Phylogenetic reconstructions were inferred using the maximum parsimony method (heuristic search). Bootstrapping (values at the nodes) was used over 1000 replicates. The KCNA type is indicated by the number following the species name. The neurotrophin-type to which they are neighbor in human genomes is indicated in bold with the human sequence reference. All but KCNA6 were included into monophyletic groups (highlighted by alternate colors) that were supported by bootstrap values of 50% and over (values in bold). Right panel: amphioxus sequences are substituted to Xenopus sequences. None of the amphioxus sequence is closer to either vertebrate KCNA type. Lower bootstrap values were obtained when amphioxus sequences were included because only truncated sequences could reliably be aligned.
Dos Santos et al. BMC Evolutionary Biology 2011 11:332 doi:10.1186/1471-2148-11-332