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Open Access Research article

Proportionality between variances in gene expression induced by noise and mutation: consequence of evolutionary robustness

Kunihiko Kaneko

Author Affiliations

Department of Basic Science, Univ. of Tokyo, and Complex Systems Biology Project, ERATO, JST, 3-8-1 Komaba, Meguro-ku, Tokyo 153-8902, Japan

BMC Evolutionary Biology 2011, 11:27  doi:10.1186/1471-2148-11-27

Published: 26 January 2011

Additional files

Additional file 1:

Figure S1 Dependence of the variances Vip(i) and Vg(i) on the noise strength. Figure S2 Correlation between gene expressions. Figure S3 Correlation between errors by noise and mutation over all genes. Figure S4 Relationship between V (i) and Vip(i) for evolved GRNs with a larger fraction of target genes, and a smaller fraction of nonzero genes. Figure S5 Relationship between Vg(i) and Vip(i) for the gene expression dynamics whose noise level depends on each gene. Figure S6 Relationship between Vg(i) and Vip(i) for a model with "extrinsic noise."

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