Figure 8.

Luciferase assay of the CR1 and CR3 regions. Transactivation activity of Smad3, Stat3 and Klf4 on the conserved regions (CR1 and CR3) was investigated by the dual-glow luciferase assay. Smad3 shows elevated transactivation activity on CR3. Stat3 leads to transcriptional repression on CR1. Klf4 binding results in a repressive effect on CR1 and CR3.

Struckmann et al. BMC Evolutionary Biology 2011 11:267   doi:10.1186/1471-2148-11-267
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