Open Access Research article

The phylogenomic analysis of the anaphase promoting complex and its targets points to complex and modern-like control of the cell cycle in the last common ancestor of eukaryotes

Laura Eme1, Aurélie Trilles1, David Moreira2 and Céline Brochier-Armanet13*

Author Affiliations

1 Aix-Marseille Université, Laboratoire de Chimie Bactérienne - UPR CNRS 9043, Marseille, France

2 Unité d'Ecologie, Systématique et Evolution - UMR CNRS 8079, Université Paris-Sud, Orsay, France

3 Present Address: Université de Lyon; Université Lyon 1; CNRS; UMR5558, Laboratoire de Biométrie et Biologie Evolutive, 43 boulevard du 11 novembre 1918, Villeurbanne, France

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BMC Evolutionary Biology 2011, 11:265  doi:10.1186/1471-2148-11-265

Published: 23 September 2011

Additional files

Additional file 1:

Table S1. Table showing the taxonomic distribution of homologues of APC/C subunits and activators in eukaryotes.

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Additional file 2:

Table S2. Table showing the taxonomic distribution of homologues of APC/C main targets in eukaryotes.

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Additional file 3:

Data S1. Bayesian phylogenetic trees inferred MrBayes (*.con files) and ML phylogenetic trees inferred with TreeFinder (*.tre files = ML topologies; *.boot.trees = topologies generated by the bootstrap analysis) for each APC/C subunit, activator and main target (except Apc9, Apc14, Apc15 and Apc16 due to a too restricted number of homologues).

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Additional file 4:

Figure S1. Bayesian phylogenetic tree of the adaptor/co-activator Cdh1 inferred with Mrbayes. Numbers at nodes correspond to posterior probabilities (PP) estimated by MrBayes and bootstrap values (BV) estimated by TreeFinder (only PP and BV greater than 0.5 and 50%, respectively, are shown). The scale bar indicates the average number of substitutions per site.

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Additional file 5:

Figure S2. Bayesian phylogenetic tree of the adaptor/co-activator Cdc20 inferred with Mrbayes. Numbers at nodes correspond to posterior probabilities (PP) estimated by MrBayes and bootstrap values (BV) estimated by TreeFinder (only PP and BV greater than 0.5 and 50%, respectively, are shown). The scale bar indicates the average number of substitutions per site.

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Additional file 6:

Table S3. Table showing the conserved functional domains present in homologues of APC/C subunits and activators.

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Additional file 7:

Table S4. Table showing the conserved functional domains present in homologues of APC/C main targets.

Format: PDF Size: 60KB Download file

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