Predicted transmembrane domain for Mouse (Mmu) DGAT1, DGAT2, ACAT1, ACAT2, MGAT1, and AWAT1 sequences. See Additional File 1 for sources. The TMHMM web tools of the Center for Biological Sequence Analysis, Technical University of Denmark TMHMM Server plots the probability of the ALDH sequence forming a transmembrane helix (0-1.0 on the y-axis) (shown in red for the relevant amino acid sequences) http://www.cbs.dtu.dk/services/TMHMM/ webcite. Eight predicted transmembrane helices are identified for each of the DGAT1, ACAT1 and ACAT2 sequences; in contrast, only one major transmembrane helix (or helices) was observed for DGAT2, MGAT1, MGAT2, AWAT1 and AWAT2 sequences; regions of all sequences predicted to be located inside or outside the membrane are shown in blue and pink, respectively. The Pfam:Mboat is represented by a dotted line to DGAT1, ACAT1 and ACAT2.
Turchetto-Zolet et al. BMC Evolutionary Biology 2011 11:263 doi:10.1186/1471-2148-11-263