Table 3

Maximum field allele frequencies for non-synonymous mutations in PfSERCA (PFA0310c, PfATP6)

Mutation

Frequency (%)

Location

Reference

R37K

100

Venezuela

[54]

K67R

3

Ghana

[54]

K88E

1

Tanzania

[54]

I89T

38

Philippines

[54]

S176N

3

Malawi

[54]

V229I

< 1

Zanzibar

[55]

I230T

3

Iran

[54]

H243Y

5

Malawi

[54]

A338V

1

Tanzania

[54]

L402V

28

Brazil

[56]

D405N

1

Tanzania

[54]

E431K

58

Ethiopia

[57]

E432K

36

Cameroon

[58]

D436N

3

Tanzania

[54]

A438D

18

Vanuatu

[54]

N462D

10

Venezuela

[54]

N463S

3

Vietnam

[59]

464 del

2

Cambodia

[60]

N465S

16

Thailand

[1]

S466N

35

Peru

[61]

S529I

3

Tanzania

[54]

K561N

1

Niger

[62]

N569K

36

Zanzibar

[55]

G585D

< 1

Zanzibar

[55]

T602I

< 1

Zanzibar

[55]

L610I

1

Tanzania

[54]

K611N

< 1

Zanzibar

[55]

N612D

< 1

Zanzibar

[55]

A621D

< 1

Zanzibar

[55]

A623E

4

Ethiopia

[57]

A630S

58

Brazil

[56]

G632E

3

Malawi

[54]

T635K

16

Madagascar

[54]

E637G

< 1

Zanzibar

[55]

G639D

90

Venezuela

[54]

S641G

< 1

Zanzibar

[55]

E643Q

1

Zanzibar

[55]

N644I

1

Zanzibar

[55]

K649E

< 1

Zanzibar

[55]

L650W

2

Bangladesh

[54]

T657I

3

Malawi

[54]

N683K

9

Bangladesh

[54]

I723V

3

Tanzania

[54]

H747Y

11

Madagascar

[54]

S769N

4

Ethiopia

[57]

K771A

4

Angola

[63]

K776N

1

Angola

[63]

K783E

1

Tanzania

[54]

G805E

3

Malawi

[54]

R809G

< 1

Zanzibar

[55]

844 del

77

Peru

[61]

D845N

3

Tanzania

[54]

E847K

2

Thailand

[1]

T857S

1

Tanzania

[54]

A1115G

4

Papua New Guinea

[54]

V1169I

24

Brazil

[54]

S1187T

3

Ghana

[54]

D1228E

3

Ghana

[54]

3D7 sequence was used as reference. Only studies where alleles were determined for at least ten samples were included. Samples with mixed infections were included in each numerator.

Gardner et al. BMC Evolutionary Biology 2011 11:257   doi:10.1186/1471-2148-11-257