Density plot of conservation vs. hydrophilicity for amino acid residues of 40 reference genes. (a) Number of occurrences at each co-ordinate (using bins of 0.1 on both × and Y-axes). (b) Average hydrophilicity (conservation score bins of 0.2). Conservation levels in P. falciparum - P. chabaudi alignments were based on BLOSUM62 score using a sliding, overlapping window of 9 residues; hydrophilicity was based on the Kyte-Doolittle index (sliding, overlapping window of 14).
Gardner et al. BMC Evolutionary Biology 2011 11:257 doi:10.1186/1471-2148-11-257