Domains in the network core are less conserved than peripheral domains. Human domains from the network's inner-most core (all at k = 10, left panel), excluding those comprised entirely of short repeating units in tandem and of varying spans, are measured for the level of sequence conservation within each domain family. The degree of conservation among all individual members of a domain family is presented as the mean and the standard deviation (error bar) of pair-wised amino acid identity (y-axis, in %) after alignment.
Xie et al. BMC Evolutionary Biology 2011 11:242 doi:10.1186/1471-2148-11-242