Evolutionary relationship of the PDZ domains from LNX2 and MUPP1. LNX2 PDZ domain sequences from A. queenslandica and a consensus vertebrate sequence, as well as PDZ domains from H. sapiens and T. adhaerens MUPP1 protein were analyzed. For each protein PDZ domains are numbered consecutively (#1, #2 etc). Using the Neighbor-Joining method, a bootstrap consensus tree was inferred from 1000 replicates and is taken to represent the evolutionary history of the sequences analyzed. The percentage of replicate trees in which the associated domains clustered together in the bootstrap test is shown next to the branches. The tree is drawn to scale, with branch lengths in the same units as those of the evolutionary distances used to infer the phylogenetic tree. Clustering of the four LNX PDZ domains with the last four domains of MUPP1 is highlighted in the shaded boxes. Con = a consensus vertebrate LNX2 sequence.
Flynn et al. BMC Evolutionary Biology 2011 11:235 doi:10.1186/1471-2148-11-235