Domain structures of mammalian LNX proteins. LNX1 and LNX2 share an identical domain structure, as do LNX3 and LNX4. LNX5 resembles LNX3 and 4 but lacks the RING and one PDZ domain. The regions of LNX3, 4 and 5 carboxy-terminal to the PDZ domains show significant sequence similarity, particularly in the last 150 amino acids that we define here as the LNX3 homology (LNX3H) domain. The number of amino acids (aa) in the murine LNX proteins are indicated. Isoforms of LNX1, 3 and 4 resulting from alternative splicing and alternative promoter usage are not shown. RF = RING finger domain; PDZ = PDZ domain; Y = NPXY motif; F = NPXY motif.
Flynn et al. BMC Evolutionary Biology 2011 11:235 doi:10.1186/1471-2148-11-235