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Open Access Highly Accessed Research article

Molecular evolution of the LNX gene family

Michael Flynn, Orthis Saha and Paul Young*

  • * Corresponding author: Paul Young p.young@ucc.ie

  • † Equal contributors

Author Affiliations

Department of Biochemistry, University College Cork, Cork, Ireland

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BMC Evolutionary Biology 2011, 11:235  doi:10.1186/1471-2148-11-235

Published: 9 August 2011

Additional files

Additional file 1:

Analysis of splicing junctions in LNX1, LNX2, LNX3, LNX4 and MUPP1 PDZ domains. An alignment of PDZ domain sequences with splicing junctions highlighted.

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Open Data

Additional file 2:

Multiple sequence alignment of LNX3, LNX4 and LNX5 and their invertebrate orthologs. An alignment of full length murine LNX3, LNX4 and LNX5, as well as LNX3/4 orthologs from diverse invertebrate species.

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Open Data

Additional file 3:

Phylogenetic tree of all human PDZ domains. Clustering of related LNX PDZ domains is highlighted in a phylogenetic tree of all human PDZ domains.

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Open Data

Additional file 4:

Conservation of ligand-binding residues in LNX1, LNX2 and MUPP1. Table showing the amino acids identified as determinants of PDZ domain specificity for LNX1, LNX2 and MUPP1.

Format: PDF Size: 101KB Download file

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Open Data

Additional file 5:

Predicted interactions of LNX1, LNX2, MUPP1 & INADl PDZ domains. Table showing predicted PDZ domain interactions for LNX1 PDZ1-4, LNX2 PDZ1-4, MUPP1 PDZ10-13 and INADl PDZ 8-10.

Format: PDF Size: 112KB Download file

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Open Data

Additional file 6:

Genbank accession numbers. Table showing Genbank accession numbers for LNX and MUPP1 homologs referred to in this study.

Format: PDF Size: 79KB Download file

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Open Data