Figure 3.

Conservation of active residues among mtMutS, MutS and MSH amino acid sequences. An amino acid alignment of a reduced set of taxa included in the phylogenetic analysis, illustrating conserved positions or motifs (black boxes) known to function in MutS/MSH-mediated MMR or HNH endonuclease activity. Numbers above alignment blocks indicate the position within the alignment, relative to the 5'-end of octocoral sequences. Vertical lines separate the three regions of homology, in order: Domain I, Domain V and the HNH endonuclease domain. Taxa lacking the HNH domain were omitted from the latter alignment.

Bilewitch and Degnan BMC Evolutionary Biology 2011 11:228   doi:10.1186/1471-2148-11-228
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