Table 4

Comparison of the accessible surface area (ASA) values of atypical amino acid replacement sites with those of all sites in gapless alignments

Skewness of atypical replacement samples to positions in the protein globule


Interior positions in globule (p)*

Surface positions in globule (p)*


Cyclin families

DSSP ASA values

10 ASA

classes

3 ASA

classes

DSSP ASA values

10 ASA

classes

3 ASA

classes


A animal

0.9966

0.9957

0.9906

0.0034

0.0043

0.0095

B animal

0.9570

0.9772

0.9678

0.0432

0.0230

0.0324

B fungal

0.6029

0.7785

0.7500

0.3983

0.2224

0.2512

B3 animal

0.9914

0.9975

0.9827

0.0087

0.0025

0.0175

D animal

0.9713

0.9200

0.8835

0.0289

0.0805

0.1173

E animal

0.9995

0.9999

0.9999

0.0005

0.0001

0.0001


*Distribution skewness was estimated using one-tailed Mann-Whitney's test.

p ≤ 0.005 is in bold, 0.005 <p ≤ 0.025 is in italics; Bonferonni's correction for simultaneous testing of two statistical hypotheses based on the same dataset: accessible surface area and atypical amino acid replacements positions.

Gunbin et al. BMC Evolutionary Biology 2011 11:224   doi:10.1186/1471-2148-11-224

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