Open Access Highly Accessed Research article

Histone variant innovation in a rapidly evolving chordate lineage

Alexandra Moosmann1, Coen Campsteijn14, Pascal WTC Jansen35, Carole Nasrallah1, Martina Raasholm1, Henk G Stunnenberg3 and Eric M Thompson12*

Author Affiliations

1 Sars International Centre for Marine Molecular Biology, Norway

2 Department of Biology University of Bergen, Norway

3 Department of Molecular Biology, Nijmegen Center for Molecular Life Sciences, Radboud University Nijmegen, The Netherlands

4 Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, and Department of Biochemistry, Institute for Cancer Research, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway

5 Department of Molecular Cancer Research, University Medical Center Utrecht, Utrecht, The Netherlands

For all author emails, please log on.

BMC Evolutionary Biology 2011, 11:208  doi:10.1186/1471-2148-11-208

Published: 15 July 2011

Additional files

Additional file 1:

Additional Tables S1-S3 and additional Figures S1-S5. Table S1. Oikopleura dioica histone genes: stem-loop sequences and expression profiles. Table S2. Histone variants retained in mature Oikopleura dioica sperm. Table S3. Primer pairs used for quantitative RT-PCR. Figure S1. Phylogenetic relationships among Oikopleura dioica histone genes. Figure S2. Histones extracted from D4 and D6 animals. Figure S3. Spectra of O. dioica histone modifications obtained by LC-MS/MS. Figure S4. Alignment of mammalian somatic and testes-specific H2B variants with the canonical H2B of O. dioica. Figure S5. Histone H3 isoforms of species with substitutions surrounding the methylation site at K79. Additional Data References.

Format: DOC Size: 4.7MB Download file

This file can be viewed with: Microsoft Word Viewer

Open Data