Open Access Research article

Genetic adaptation of the antibacterial human innate immunity network

Ferran Casals12*, Martin Sikora16, Hafid Laayouni1, Ludovica Montanucci1, Aura Muntasell3, Ross Lazarus4, Francesc Calafell1, Philip Awadalla2, Mihai G Netea5 and Jaume Bertranpetit1

Author Affiliations

1 Institute of Evolutionary Biology (UPF-CSIC), CEXS - UPF - PRBB, Barcelona, Catalonia, Spain

2 Centre de Recherche, CHU Sainte-Justine, Université de Montréal, Montréal, Québec H3T 1C5, Canada

3 Unitat d'Immunologia, IMIM-Hospital del Mar, Barcelona, Catalonia, Spain

4 Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA

5 Department of Medicine, Radboud University Nijmegen Medical Center, 6500 HB Nijmegen, The Netherlands

6 Department of Genetics, Stanford University School of Medicine, Stanford, USA

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BMC Evolutionary Biology 2011, 11:202  doi:10.1186/1471-2148-11-202

Published: 11 July 2011

Additional files

Additional file 1:

Additional Figures and Tables. Additional figures and tables containing the comparison of nucleotide diversity in Africans and Europeans (Figure S1), the correlation between nucleotide diversity for the whole sequence and the degree and betweenness centrality (Figure S2), the correlation between nucleotide diversity for the coding sequence and the degree and betweenness centrality (Figure S3), the correlation between divergence and the degree and betweenness centrality (Figure S4), the comparison of the mean nucleotide diversity in each functional class for the whole sequence to the empirical distributions obtained from 10,000 permutations (Figure S5), the comparison of the mean nucleotide diversity in each functional class for the coding sequence to the empirical distributions obtained from 10,000 permutations (Figure S6), a list of the genes included in the study and their functional classification (Table S1), the mean divergence values in the different functional classes (TableS2), and the significance of the neutrality tests estimated by using coalescent simulations (Table S3).

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