Schematic representation of protein conservation in the GSIS biochemical network. Proteins are represented as circles with shading representing their level of sequence similarity between human and mouse (see Table 1). Darkly shaded proteins are most similar and lightly shaded proteins least similar. Five shades of grey are used to represent the five quintiles of the sequence similarity distribution. Proteins are separated between cytoplasm, mitochondrial membrane and mitochondrial matrix, grouped together into sub-pathways and co-localised to give an approximate representation of their functional relationships.
Ainali et al. BMC Evolutionary Biology 2011 11:142 doi:10.1186/1471-2148-11-142