Open Access Research article

Protein coalitions in a core mammalian biochemical network linked by rapidly evolving proteins

Chrysanthi Ainali1, Michelle Simon2, Shiri Freilich3, Octavio Espinosa245, Lee Hazelwood2, Sophia Tsoka1, Christos A Ouzounis16* and John M Hancock2*

Author Affiliations

1 Centre for Bioinformatics, Department of Informatics, School of Natural and Mathematical Sciences, King's College London, Strand, London WC2R 2LS, UK

2 Bioinformatics Group, MRC Harwell, Harwell Science and Innovation Campus, Oxfordshire OX11 0RD, UK

3 The Blavatnik School of Computer Sciences & Sackler School of Medicine, Tel Aviv University, Ramat Aviv 69978, Israel

4 Department of Biochemistry, University of Oxford, UK, South Parks Road, Oxford, OX1 3QU, UK

5 Institute of Cancer Research, Chester Beattie Laboratories, London SW3 6JB, UK

6 Computational Genomics Unit, Institute of Agrobiotechnology, Centre for Research & Technology Hellas (CERTH), GR-57001 Thessalonica, Greece

For all author emails, please log on.

BMC Evolutionary Biology 2011, 11:142  doi:10.1186/1471-2148-11-142

Published: 25 May 2011

Additional files

Additional file 1:

Overview of the GSIS network. Reactions are represented as arrows (which may be uni- or bidirectional) and labelled in green v1 to v53 according to [7] which also provides a key to abbreviations. Metabolites are labelled in black. Enzymes catalysing reactions are labelled in brown.

Format: TIFF Size: 403KB Download file

Open Data