Table 1

Parameters used in the model

Parameter

Description


nF

Density of wild-type/plasmid-free cells ('F' in figures)

nC

Density of cells with resistance on the chromosome ('C' in figures)

nP

Density of cells infected with a resistance-carrying plasmid ('Plasmids' in figures)

nB

Density of cells infected with a non-coding plasmid ('B' in figures)

nCP

Density of cells with resistance both on the chromosome and on a plasmid ('CP' in figures)

nCB

Density of cells infected with a non-coding plasmid, and with resistance on the chromosome ('CB' in figures)

N

Total density of cells

N = nF+nC+nP+nB+nCP+nCB

A

Concentration of antibiotic

l

Rate of decay of antibiotic

θ

Treatment dosage of antibiotic

τ

Interval between antibiotic treatments

r

Intrinsic per-capita growth rate of cells

a

Extrinsic density-dependent death rate of cells

m

Death rate of non-resistant cells, due to antibiotic

cC

Cost of antibiotic resistance when gene carried on chromosome

cP

Cost of antibiotic resistance when gene carried on plasmid

x

Cost of plasmid carriage

β

Rate of horizontal transfer of plasmids

s

Rate of segregation


Svara and Rankin BMC Evolutionary Biology 2011 11:130   doi:10.1186/1471-2148-11-130

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