The effect of antibiotic dosage intensity and the interval between treatments on the cell types persisting at equilibrium for the full model (consisting of wild-type cells, cells with resistance on the chromosome, plasmids carrying resistance and plasmids with no resistance). "F" denotes wild-type cells, "P" denotes cells infected with a plasmid carrying resistance and "C" denotes cells with resistance on the chromosome and "B" denotes cells carrying plasmids that do not code for resistance genes. Here, plasmid-carried resistance is favoured when dosage and interval between treatments are high. Cell types that are present in the population at a density greater than exceeding 0.001 are shown. The plots were calculated by running the simulation for a number of parameter values for 5,000 time-steps. Lines were then smoothed by interpolation. Parameters used are r = 1, a = 1, β = 0.1, cc = 0.02, cp = 0.02, x = 0.05, m = 0.1, s = 0.001 and l = 0.5.
Svara and Rankin BMC Evolutionary Biology 2011 11:130 doi:10.1186/1471-2148-11-130